Metastases, a similar genetic profile, the primary tumor
Hamburg, Germany: The work of scientists in the Netherlands, the idea that breast cancer metastases behave differently than primary tumors have been refused. Said graduate student, Britta Weigelt the meeting of the 4th European Breast Cancer Conference (today, Thursday, 18 March) that, contrary to what was previously thought, every cell in primary breast cancer had cancer cells may be secondary, which then spread to other parts of the body. These tumor cells produced a very similar genetic parents and cells had behaved like that.Therefore, metastases could have the same answer to a particular treatment of the primary tumor.The discovery has implications for the treatment of breast cancer once researchers have identified ways in which genetically different tumors respond to
a variety of therapies. Based on the genetic profile of a tumor patient, doctors can choose the best treatment for this particular tumor type (some types of chemotherapy, radiation or hormonal) and treat the patient with her from the time of diagnosis . These principles (neoadjuvant) treatment can not only reduce the primary tumor, but may also prevent the proliferation of micrometastases, thereby saving lives, as metastases that occur in other body parts are very difficult to treat successfully and are the leading cause of death in breast cancer.Mrs Weigelt said: so far largely unknown whether the characteristics of breast cancer that define the rate of growth and treatment response were similar in the primary tumor metastasis. In addition, it is unclear whether all cells
of primary breast cancer were capable of metastasis or only some of them. In the first study to do this, Mrs Weigelt and colleagues at the Netherlands Cancer Institute in Amsterdam, the activity of genes compared to primary breast tumor samples from 15 patients and metastases to lymph nodes play, and coordinated primary tumors with metastases in more distant parts of the body had spread in eight patients.We have
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