New insights into HIV immunity suggest alternative approach to vaccines

The new findings by researchers at Duke University Medical Center to understand how HIV escapes the immune system of humans, a new concept for the development of vaccines against HIV. The findings suggest some HIV vaccines have failed because they are a class of antibodies that the immune system of a patient is able to induce programmed to destroy. The Duke team discovered that certain broadly protective antibodies that recognize and adhere to the protein of HIV gp41, resemble antibodies in autoimmune diseases.
Prevent attacks, urges against himself The Duke study, HIV vaccine failed in part because certain proteins on HIVs outer coat trigger only short-term, self-reactive antibodies instead of long duration, HIV-specific antibodies. The results also imply that duringearly infection in humans, HIV may escape destruction by the immune system because these seemingly vulnerable outer coat proteins activate self-reactive antibodies.
Humans or animals, no broadly neutralizing antibodies - those antibodies that kill most HIV strains - done. This provides a plausible explanation as to why the usually protective antibodies in response to currently tested as non-vaccine against HIV has been made, said Barton Haynes, MD, lead author of the study and director of the Institute at Duke Human Vaccine University Medical Center. The researchers will report their findings in an upcoming issue of Science.
2005, Science Express. The antibody-producing part of the human immune system is basically divided into two categories. Immunity first, innate Bcell antibodies is composed of fast-acting but weak to fight a wide range of pathogens. These antibodies can also attack the body itself, as in autoimmune diseases like lupus erythematosus. When viruses activate innate B cells, the body destroys the B cells to protect against the antibodies that cause autoimmune disease or other damage.
The second category of adaptive immune system of B cell immunity, a slower response

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